"Detection of prostate enlargement, which may or may not lead to prostate cancer, is largely based on serum PSA levels. But PSA level is not a definitive marker and could sometimes be misleading. Therefore, additional and more definitive markers are still under investigation. The finding that MIC-1 is consistently over expressed in prostate cancer patients could serve as a valuable marker, additional to serum PSA, and a correlation between the two could in future act as a valuable diagnostic tool,” commented Prof. Urmi Chatterji of Cancer Research Laboratory at University of Calcutta, who was not connected with the study. “However, level of expression of MIC-1 in terms of a range of values in healthy individuals versus those with benign enlargement and cancer patients need to be ascertained for more specific diagnostic purpose," she said.